Biology · IGCSE 0610 · §9.1–9.4

Transport in Animals

How the heart and blood vessels move blood around the body, and what the blood carries.

Biology · 0610 Topic 9 of 18

Circulatory Systems

Transport in animalsA pump, vessels and blood§9.1 · CirculationPump, valves,one-way flow§9.2 · The heartStructure, activity,disease§9.3 · Blood vesselsArteries, veins,capillaries§9.4 · BloodCells and plasmatogetherThe heart pumps blood through vessels to every cell,carrying oxygen, nutrients and wastesone-way valves keep the blood moving in one direction
FIG 9.0 How the chapter connects: The heart pumps blood through a closed system of vessels. The blood carries cells, nutrients, oxygen and wastes to and from every part of the body.

Large animals cannot rely on diffusion alone to supply their cells. They have a circulatory system: the heart pumps blood around the body in blood vessels.

Definition
Circulatory system
A system of blood vessels with a pump and valves to ensure one-way flow of blood.
heart: the pumpvessels: arteries, veins, capillariesblood: cells in plasma
FIG 9.9 The heart, a blood vessel and the cells of the blood.
PartRole
Blood vesselsCarry the blood to and from the organs
Heart (pump)Pushes the blood around
ValvesStop backflow, so flow is one-way

ExtendedSingle circulation of a fish

In a fish the blood passes through the heart once on each complete circuit. The heart pumps deoxygenated blood to the gills, where it picks up oxygen. The oxygenated blood then flows on to the body and returns to the heart.

heartgillsbodydeoxygenatedoxygenatedback to the heart
FIG 9.1 Single circulation of a fish.

ExtendedDouble circulation of a mammal

In a mammal the blood passes through the heart twice on each complete circuit. The right side pumps deoxygenated blood to the lungs; it returns oxygenated to the left side, which pumps it to the body. Blood returns from the body deoxygenated, to the right side.

lungsbody (all other organs)heartpulmonary arterypulmonary veinaortavena cavaoxygenated blooddeoxygenated blood
FIG 9.2 Double circulation of a mammal.

Advantage: blood loses pressure in the lung capillaries, so returning it to the heart lets it be pumped again. It reaches the body at higher pressure and flows faster.

Examiner note
Name all three parts: vessels, a pump (the heart) and valves. The valves are what make the flow one-way.
Why this matters
Blood must reach every cell to deliver oxygen and nutrients and to remove wastes. A pump moves it much faster than diffusion could.

The Heart

The mammalian heart is a muscular organ divided by a septum into a right side and a left side. Each side has an upper atrium and a lower ventricle.

Definition
Coronary arteries
The arteries on the surface of the heart that supply the heart muscle with blood.
vena cavaright atriumvalveright ventricleaortaleft atriumpulmonary veinleft ventriclecoronary arterymuscular wallseptumpulmonary artery
FIG 9.3 The mammalian heart in section (schematic).
VesselCarries bloodBetween
Vena cavato the heartbody and right atrium
Pulmonary arteryaway from the heartright ventricle and lungs
Pulmonary veinto the heartlungs and left atrium
Aortaaway from the heartleft ventricle and body

The atria receive blood and the ventricles pump it out. One-way valves in the heart prevent backflow.

ExtendedValves, walls and the septum

The valves between atria and ventricles are the atrioventricular valves; those at the base of the aorta and pulmonary artery are the semilunar valves. The left ventricle has a thicker muscle wall than the right, because it pumps blood at high pressure to the whole body, while the right pumps blood a short distance to the lungs at lower pressure. The ventricles have thicker walls than the atria, because they pump blood out of the heart at higher pressure, while the atria only push blood into the ventricles. The septum keeps oxygenated and deoxygenated blood apart, so the blood pumped to the body is fully oxygenated.

Examiner note
Do not say the vena cava or aorta “go into” the heart without direction. Use to or from: the aorta carries blood from the left ventricle.
Why this matters
The heart muscle needs its own blood supply, because it works without rest. The animal’s left side appears on the right of the diagram, as you view it from the front.

The Heart in Action

Blood is pumped away from the heart in arteries and returns to the heart in veins. The activity of the heart may be monitored in three ways.

Definition
Pulse rate
The number of times per minute that the pulse is felt in an artery, equal to the heart rate.
MethodWhat is measured
ECGElectrical activity of the heart (electrocardiogram)
Pulse rateBeats felt in an artery, such as at the wrist
Listening to the valvesThe sounds of the valves closing

Investigating exercise and heart rate

Count the pulse for a set time at rest. Take exercise, such as stepping or jogging, for a fixed time. Count the pulse again straight afterwards, then at regular intervals until it returns to the resting value. Heart rate increases during exercise and takes time to recover.

60801001201401600246810121416restexerciserecoverytime (minutes)heart rate (beats per minute)
FIG 9.4 Typical change in heart rate with exercise (idealised).

ExtendedHow the heart works and why exercise raises heart rate

Blood flows into the atria, which contract and push it into the ventricles. The ventricles then contract and force the blood out into the arteries. The valves open to let blood through and close to stop it flowing back.

During exercise the muscles respire faster, so the heart beats faster to deliver more oxygen and glucose and to remove carbon dioxide more quickly.

Examiner note
For an investigation, give the independent variable (the activity), the dependent variable (pulse rate) and control the time and the person.
Why this matters
Heart rate rises during exercise, so it is a simple measure of how hard the body is working.

Coronary Heart Disease

In coronary heart disease the coronary arteries become blocked by fatty deposits. Less blood reaches the heart muscle, so it receives less oxygen.

Definition
Coronary heart disease
A disease in which the coronary arteries are blocked by fatty deposits, reducing the blood supply to the heart muscle.
healthy coronary arteryblood flows freelyfatty deposit narrows the lumenless blood reaches the heart muscle
FIG 9.5 A healthy coronary artery and one narrowed by fatty deposits.

Risk factors

Risk factorExample
DietMuch saturated fat and salt
Lack of exerciseLittle physical activity
StressLong periods of stress
SmokingTobacco smoke damages the arteries
Genetic predispositionInherited tendency in the family
Age and sexRisk rises with age; higher in males

Diet and exercise

A diet low in saturated fat and salt, and regular exercise, reduce the risk. Exercise strengthens the heart muscle and helps to control body mass. Neither removes the risk completely, since age, sex and genes cannot be changed.

Examiner note
Link cause to effect: blocked coronary artery, less oxygen and glucose reach the heart muscle, and so less respiration in that region.
Why this matters
It is a leading cause of death worldwide, and several risk factors can be changed.

Blood Vessels

Three types of vessel carry the blood: arteries, veins and capillaries.

arterythick muscular wallnarrow lumenno valvesveinthin wallwide lumenvalvescapillarywall one cell thickvery narrow lumenno valvesvein valvestops backflow
FIG 9.6 Arteries, veins and capillaries in section (schematic).
VesselWallLumenOther features
ArteryThickNarrowCarries blood away from the heart
VeinThinWideHas valves; carries blood to the heart
CapillaryOne cell thickVery narrowLinks arteries and veins

Capillaries allow the exchange of materials between the blood and the cells of the tissues.

ExtendedStructure and function

Arteries carry blood at high pressure, so they have thick, strong walls and a narrow lumen. Veins carry blood at low pressure, so their walls are thinner, their lumen is wide and valves stop backflow. Capillaries have walls one cell thick, giving a short diffusion distance. They are very narrow and permeable, so they pass close to every cell.

Definition
Lumen
The hollow space inside a tube, through which the blood flows.
Examiner note
Describe three features for each vessel: wall thickness, lumen size and valves. Do not say arteries are “thick” without saying the wall.
Why this matters
Arteries, veins and capillaries each have a different structure, and the differences are easy to test.

The Main Blood Vessels

You need to identify the main vessels to and from the heart, the lungs and the kidneys.

OrganVesselCarries
HeartVena cavaBlood from the body to the heart
AortaBlood from the heart to the body
Pulmonary arteryBlood from the heart to the lungs
Pulmonary veinBlood from the lungs to the heart
LungsPulmonary arteryDeoxygenated blood to the lungs
Pulmonary veinOxygenated blood from the lungs
KidneyRenal arteryBlood to the kidney
Renal veinBlood from the kidney

ExtendedVessels of the liver

Three vessels serve the liver. The hepatic artery brings oxygenated blood to the liver. The hepatic portal vein brings blood from the small intestine, carrying absorbed nutrients. The hepatic veins carry blood away from the liver.

Worked example (naming the vessel): Name the vessel that carries blood from the left ventricle to the body. Step 1. The left ventricle pumps blood away from the heart. Step 2. A vessel carrying blood away from the heart is an artery. Step 3. It leads to the whole body, so it is the aorta. Answer: Aorta.

Examiner note
Learn the vessels in pairs. The pulmonary artery carries deoxygenated blood, an exception to the idea that arteries carry oxygenated blood.
Why this matters
Naming the vessel correctly depends on its direction of flow, not on the colour of the blood.

Components of Blood

Blood has four components: red blood cells, white blood cells, platelets and plasma.

Definition
Haemoglobin
A red pigment in red blood cells that combines with oxygen to carry it around the body.
red blood cell: no nucleuswhite blood cell: has a nucleusplatelets: cell fragmentsplasma: the liquid
FIG 9.7 Components of blood (schematic).
ComponentFeatureFunction
Red blood cellBiconcave disc, no nucleus, contains haemoglobinTransports oxygen
White blood cellHas a nucleusPhagocytosis and antibody production
PlateletCell fragmentClotting
PlasmaPale yellow liquidTransports blood cells, ions, nutrients, urea, hormones and carbon dioxide
Examiner note
Say red blood cells transport oxygen, and that haemoglobin is the pigment that carries it. Do not say they carry “air”.
Why this matters
Without haemoglobin the blood could not carry enough oxygen to meet the needs of the cells.

White Cells and Clotting

White blood cells defend the body against pathogens in two ways: by phagocytosis and by antibody production.

Definition
Phagocytosis
The engulfing and digesting of pathogens by a white blood cell.

Blood clotting

When a vessel is cut, the blood forms a clot. The platelets are involved in clotting. Clotting has two roles: it prevents blood loss and it prevents the entry of pathogens.

ExtendedLymphocytes and phagocytes

A phagocyte has a lobed or irregular nucleus and engulfs pathogens by phagocytosis. A lymphocyte has a large round nucleus that fills most of the cell, and produces antibodies.

phagocyteengulfs pathogenslymphocytemakes antibodies
FIG 9.8 A phagocyte and a lymphocyte (schematic).

ExtendedThe clotting process

Clotting is the conversion of soluble fibrinogen to insoluble fibrin. The fibrin forms a mesh of fibres across the wound, which traps blood cells and forms the clot.

Examiner note
State both roles of clotting: it prevents blood loss and prevents the entry of pathogens. One alone loses a mark.
Why this matters
A clot seals a wound, which stops bleeding and keeps pathogens out while the tissue heals.

Exam advice

Common mistakes

Saying arteries carry oxygenated blood and veins deoxygenated
Arteries carry blood away from the heart and veins to it. The pulmonary artery is deoxygenated; the pulmonary vein is oxygenated.
Saying veins have “thick walls” or arteries have “big holes”
Arteries: thick wall, narrow lumen. Veins: thin wall, wide lumen, valves.
Saying a clot is blood “going hard”
Soluble fibrinogen is converted to insoluble fibrin, which forms a mesh.
Saying red blood cells carry “oxygen” with no mention of haemoglobin
Haemoglobin in the red cells combines with oxygen to carry it.
Giving one role of clotting
Clotting prevents blood loss and prevents the entry of pathogens.

Model answer

Describe coronary heart disease and state two risk factors.
[4 marks]
Mark 1
[k] The blockage.
The coronary arteries become blocked (by fatty deposits).
Mark 2
[k] The effect.
Less blood and oxygen reach the heart muscle.
Mark 3
[k] Risk factor one.
A diet high in saturated fat (or salt).
Mark 4
[k] Risk factor two.
A different factor: smoking, lack of exercise, stress, genes, age or sex.

Recall checklist

  • Describe the circulatory system.
  • Label the heart and the four main vessels attached to it.
  • Name three ways to monitor the heart.
  • Describe the effect of exercise on heart rate.
  • Describe coronary heart disease; discuss diet and exercise.
  • Compare an artery, vein and capillary.
  • Name the vessels to and from the heart, lungs and kidney.
  • State the functions of the blood components and the roles of clotting.
  • Explain double circulation, heart action, wall thickness and the clotting process (Extended)

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