Biology · IGCSE 0610 · §13.1

Excretion in Humans

How the body gets rid of carbon dioxide, urea, and excess water and ions.

Biology · 0610 Topic 13 of 22

Excretion

Excretion in humansRemoving waste products from the bodyExcretory productsCarbon dioxide,urea, water, ionsUrinary systemKidneys, ureters,bladder, urethraKidney structure, nephronEXT onlyLiver and ureaEXT onlytogetherWaste products of the body’s reactions are removedthrough the lungs and in the urine from the kidneysso that they do not build up and harm the body
FIG 13.0 How the chapter connects: Waste products are removed from the body. Carbon dioxide leaves through the lungs, and the kidneys remove urea and excess water and ions in the urine.

Many chemical reactions take place in the body, and some make waste products. These waste products are removed by excretion.

Definition
Excretion
The removal from organisms of toxic materials, the waste products of metabolism and substances in excess of requirements.
kidneys: urea, water, ionsliver (EXT): makes urealungs: carbon dioxide
FIG 13.5 Organs involved in excretion: kidneys and lungs; the liver’s role is Supplement (EXT).
Excretory productExcreted throughNotes
Carbon dioxideThe lungsBreathed out; see Chapter 11
UreaThe kidneysIn the urine
Excess waterThe kidneysIn the urine
Excess ionsThe kidneysIn the urine

The organs of excretion

The lungs excrete carbon dioxide. The kidneys excrete urea and excess water and ions, which leave the body in the urine. Only substances that the body has made as waste, or has in excess, are excreted.

Worked example (naming the organ): Name the organ that excretes carbon dioxide and the organ that excretes urea. Step 1. Carbon dioxide leaves the body through the lungs. Step 2. Urea is excreted by the kidneys, in the urine. Answer: Lungs; kidneys.

Excess water and ions

Water and ions are needed by the body, but any excess must be removed. The kidneys excrete the excess in the urine, so the amount of water and ions in the body does not rise too far.

Worked example (classifying a substance): Is a drink of water that the body does not need an excretory product? Name the organ that removes the excess. Step 1. Water in excess of requirements is excreted. Step 2. The kidneys remove the excess water in the urine. Answer: Yes; the kidneys.

Examiner note
Do not confuse excretion with egestion (Chapter 7). Excretion removes waste made by the body’s cells; egestion removes undigested food.
Why this matters
Waste products and substances in excess must be removed to keep the body working.

The Urinary System

The kidneys, ureters, bladder and urethra make up the urinary system. Urine is made in the kidneys and leaves the body through the urethra.

kidneyureterbladderurethraaortavena cavarenal arteryrenal vein
FIG 13.1 The human urinary system.
PartDescription
KidneysTwo organs that remove urea and excess water and ions from the blood
UretersTubes that carry urine from the kidneys to the bladder
BladderA muscular bag that stores urine
UrethraThe tube that carries urine from the bladder to the outside

Worked example (tracing the urine): Give the order of the structures through which urine passes after it is made. Step 1. Urine leaves the kidney in the ureter. Step 2. It is stored in the bladder. Step 3. It leaves the body through the urethra. Answer: Kidney, ureter, bladder, urethra.

Examiner note
Do not confuse the ureters with the urethra. There are two ureters, one from each kidney; there is one urethra, from the bladder to the outside.
Why this matters
Urine is stored in the bladder, so it can be released when it is convenient.

Structure of the Kidney

ExtendedKidney in section

A section through a kidney shows two regions: an outer cortex and an inner medulla. Blood enters in the renal artery and leaves in the renal vein. Urine leaves in the ureter.

Definition
Cortex
(Extended) The outer region of the kidney.
Definition
Medulla
(Extended) The inner region of the kidney.
cortexmedullaureterrenal arteryrenal vein
FIG 13.2 A kidney in section (schematic).

ExtendedTwo regions

RegionPosition
CortexThe outer part of the kidney
MedullaThe inner part of the kidney, inside the cortex

Worked example (identifying the region): A section of a kidney shows an outer region and an inner region. Name the inner region. Step 1. The cortex is the outer layer of the kidney. Step 2. The region inside it is the medulla. Answer: Medulla.

Examiner note
The cortex is the outer layer and the medulla lies inside it. Learn the order from the outside in.

The Nephron

ExtendedStructure of a nephron

Each kidney contains many nephrons. A nephron is a tube with blood vessels closely associated with it. At one end is a ball of capillaries called the glomerulus.

Definition
Nephron
(Extended) A tiny tube in the kidney that, with its blood vessels, filters the blood and forms urine.
blood leavesglomerulusfiltration: water, glucose,reabsorption of all glucose,urine to the uretertubulecapillaryurea and ions leave the bloodsome ions and most water
FIG 13.3 A nephron and its associated blood vessels (schematic).

ExtendedFunction of a nephron

StageWhat happens
FiltrationThe glomerulus filters water, glucose, urea and ions from the blood
ReabsorptionThe nephron reabsorbs all of the glucose, some of the ions and most of the water back into the blood
Urine formationUrine forms, containing urea, excess water and excess ions

Worked example (explaining the absence of glucose): Explain why urine from a healthy person contains no glucose. Step 1. The glomerulus filters glucose from the blood into the nephron. Step 2. The nephron reabsorbs all of the glucose back into the blood. Answer: All glucose is reabsorbed.

Examiner note
Keep to the outline: glomerulus filters, the nephron reabsorbs, urine forms. Details of the processes are not required.
Why this matters
The kidneys must return useful substances to the blood and remove only the waste and excess.

The Liver and Urea

ExtendedAssimilation of amino acids

Amino acids absorbed from digested protein are carried to the liver. The liver converts amino acids to proteins: this is the assimilation of amino acids.

Definition
Assimilation
(Extended) The movement of digested food molecules into the cells of the body, where they are used and become part of the cells.

ExtendedDeamination and urea

Amino acids that are in excess are not stored. In the liver the nitrogen-containing part of each is removed. This is deamination, and it forms urea. Urea is formed in the liver from excess amino acids. It passes into the blood, is carried to the kidneys, and is excreted in the urine.

Definition
Deamination
(Extended) The removal of the nitrogen-containing part of amino acids to form urea.
protein in foodamino acidsliverbody proteins madeexcess: deaminationureablood to the kidneysurine
FIG 13.4 Fate of amino acids in the liver (schematic).

Worked example (where is urea made?): State where urea is formed and what it is formed from. Step 1. Urea is formed in the liver. Step 2. It comes from excess amino acids, by deamination. Answer: In the liver, from excess amino acids.

Examiner note
State where urea is made (the liver) and where it is excreted (the kidneys). Urea is not made in the kidneys.

Putting It Together

Each waste product has a source and an organ that removes it from the body.

ProductExcreted byLeaves the body
Carbon dioxideLungsBreathed out
UreaKidneysIn urine, through the urethra
Excess waterKidneysIn urine, through the urethra
Excess ionsKidneysIn urine, through the urethra

ExtendedWhy excretion is important

Urea is toxic: if it built up in the body it would be harmful. Excretion by the kidneys removes the urea from the blood, so its concentration stays low.

ExtendedTracing urea

Excess amino acids are deaminated in the liver, which forms urea. The urea is carried in the blood to the kidneys. The glomerulus filters it from the blood, and it leaves in the urine.

Worked example (explaining the importance): Explain why it is important that urea is excreted. Step 1. Urea is toxic to the body. Step 2. Excretion removes it, so it does not build up. Answer: Urea is toxic.

Examiner note
Trace a substance from where it is made to where it leaves: urea is made in the liver, carried in the blood to the kidneys, and leaves in the urine.
Why this matters
Each excretory product has its own source and its own route out of the body.

Exam advice

Common mistakes

Confusing excretion with egestion
Excretion removes the body’s waste products; egestion removes undigested food as faeces.
Saying the kidneys excrete carbon dioxide
The lungs excrete carbon dioxide. The kidneys excrete urea and excess water and ions.
Mixing up the ureters and the urethra
Ureters: kidney to bladder. Urethra: bladder to outside.
Saying urea is made in the kidneys
Urea is made in the liver, by deamination of excess amino acids.
Saying urine contains glucose
All of the glucose is reabsorbed into the blood.

Model answer

Describe the path taken by urine from its formation to leaving the body.
[4 marks]
Mark 1
[k] Formation.
Urine is made in the kidney.
Mark 2
[k] Ureter.
It passes down the ureter to the bladder.
Mark 3
[k] Bladder.
It is stored in the bladder.
Mark 4
[k] Urethra.
It leaves the body through the urethra.

Recall checklist

  • Define excretion.
  • State which organ excretes each product.
  • Identify the parts of the urinary system.
  • Trace the path of urine out of the body.
  • Identify the cortex and medulla (Extended)
  • Outline the function of a nephron (Extended)
  • Describe assimilation and deamination (Extended)
  • Explain why urea must be excreted (Extended)

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